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Dnncha/README.md

Donncha O’Toole

I build open-source bioinformatics tools and investigate the code behind scientific results, based in Ireland.

X / @dnncha · Notchbird

Bioinformatics software

  • DotMatch — deterministic assignment of sequencing reads to known CRISPR guides, inline barcodes, primers and other targets. Source.
  • Turbo Picard — selected Picard-compatible preprocessing and quality-control commands in Rust. An evaluation release: assess compatibility one pipeline step at a time.

Scientific red-teaming

I check calculations in scientific software, write tests for bugs I find and propose fixes. So far, this has covered sequence processing, genomic intervals, statistics and single-cell benchmarks.

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  1. turbo-picard turbo-picard Public

    Picard-compatible Rust tools for faster SAM/BAM/CRAM, VCF, duplicate-marking and sequencing-QC workflows.

    Rust 4

  2. dotmatch dotmatch Public

    Fast exact short-DNA known-target assignment for CRISPR guides, barcodes, primers, panels, and whitelists.

    Python 1