diff --git a/src/dstack/_internal/proxy/gateway/resources/nginx/service.jinja2 b/src/dstack/_internal/proxy/gateway/resources/nginx/service.jinja2
index 7c8a5fcc9..4f2adda38 100644
--- a/src/dstack/_internal/proxy/gateway/resources/nginx/service.jinja2
+++ b/src/dstack/_internal/proxy/gateway/resources/nginx/service.jinja2
@@ -89,6 +89,9 @@ server {
         proxy_set_header X-Real-IP $remote_addr;
         proxy_set_header Host $host;
         proxy_read_timeout 300s;
+        {% if not proxy_buffering %}
+        proxy_buffering off;
+        {% endif %}
         {% else %}
         return 503;
         {% endif %}
diff --git a/src/dstack/_internal/proxy/gateway/services/nginx.py b/src/dstack/_internal/proxy/gateway/services/nginx.py
index 74581c647..1486ea0c2 100644
--- a/src/dstack/_internal/proxy/gateway/services/nginx.py
+++ b/src/dstack/_internal/proxy/gateway/services/nginx.py
@@ -68,6 +68,7 @@ class ServiceConfig(SiteConfig):
     replicas: list[ReplicaConfig]
     has_router_replica: bool = False
     cors_enabled: bool = False
+    proxy_buffering: bool = True
 
 
 class ModelEntrypointConfig(SiteConfig):
diff --git a/src/dstack/_internal/proxy/gateway/services/registry.py b/src/dstack/_internal/proxy/gateway/services/registry.py
index 592a96492..c69b57136 100644
--- a/src/dstack/_internal/proxy/gateway/services/registry.py
+++ b/src/dstack/_internal/proxy/gateway/services/registry.py
@@ -62,6 +62,7 @@ async def register_service(
         replicas=(),
         has_router_replica=has_router_replica,
         cors_enabled=cors_enabled,
+        proxy_buffering=model is None,
     )
 
     async with lock:
@@ -407,6 +408,7 @@ async def get_nginx_service_config(
         replicas=sorted(replicas, key=lambda r: r.id),  # sort for reproducible configs
         has_router_replica=service.has_router_replica,
         cors_enabled=service.cors_enabled,
+        proxy_buffering=service.proxy_buffering,
     )
 
 
diff --git a/src/dstack/_internal/proxy/lib/models.py b/src/dstack/_internal/proxy/lib/models.py
index 53eb13e74..511f27d70 100644
--- a/src/dstack/_internal/proxy/lib/models.py
+++ b/src/dstack/_internal/proxy/lib/models.py
@@ -63,6 +63,9 @@ class Service(ImmutableModel):
     replicas: tuple[Replica, ...]
     has_router_replica: bool = False
     cors_enabled: bool = False  # only used on gateways; enabled for openai-format models
+    proxy_buffering: bool = True
+    """Only used on gateways. Disabled for services with a model so that streamed responses
+    reach the client as the replica emits them."""
 
     @model_validator(mode="before")
     @classmethod
diff --git a/src/tests/_internal/proxy/gateway/routers/test_registry.py b/src/tests/_internal/proxy/gateway/routers/test_registry.py
index 20a0e148c..48c7a41d5 100644
--- a/src/tests/_internal/proxy/gateway/routers/test_registry.py
+++ b/src/tests/_internal/proxy/gateway/routers/test_registry.py
@@ -226,6 +226,13 @@ async def test_register_with_model(self, tmp_path: Path, system_mocks: Mocks) ->
                 format_spec=OpenAIChatModelFormat(prefix="/v1"),
             )
         ]
+        resp = await client.post(
+            "/api/registry/test-proj/services/test-run/replicas/register",
+            json=register_replica_payload(),
+        )
+        assert resp.status_code == 200
+        conf = (tmp_path / "sites-enabled" / "443-test-run.gtw.test.conf").read_text()
+        assert "proxy_buffering off;" in conf
 
     async def test_register_with_rate_limits(self, tmp_path: Path, system_mocks: Mocks) -> None:
         client = make_client(tmp_path)
@@ -325,6 +332,7 @@ async def test_register(self, tmp_path: Path, system_mocks: Mocks) -> None:
         assert (m1 := re.search(r"server unix:/(.+)/replica.sock;  # replica xxx-xxx", conf))
         assert (m2 := re.search(r"server unix:/(.+)/replica.sock;  # replica yyy-yyy", conf))
         assert m1.group(1) != m2.group(1)
+        assert "proxy_buffering" not in conf
         assert system_mocks.reload_nginx.call_count == 3
         assert system_mocks.open_conn.call_count == 2